N-Boc-4-hydroxy-L-proline methyl ester ( —— )

产品货号. M32701 CAS No. 102195-79-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

N-Boc-4-hydroxy-L-proline methyl ester
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

N-Boc-cis-4-hydroxy-L-proline methyl ester 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。N-Boc-cis-4-hydroxy-L-proline methyl ester 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
产品描述

N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
体外实验

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
体内实验

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同义词

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通路

Antibody Drug Conjugates (ADC)
靶点

ADCs Linker/Click Chemistry
受体

ADC Linker
研究领域

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适应症

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