Justicidin A ( —— )

产品货号. M32674 CAS No. 25001-57-4

Justicidin A is a type of bioactive chemical from Justica procumbens.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥12825	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Justicidin A
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Justicidin A is a type of bioactive chemical from Justica procumbens.
产品描述

Justicidin A is a type of bioactive chemical from Justica procumbens.
体外实验

Cell Viability Assay Cell Line:HT-29, HCT 116, SiHa, MCF7 and T24 cells Concentration:0-2.5 μM Incubation Time:6 days Result:Inhibited cell growth in a dose-dependent manner.Apoptosis AnalysisCell Line:HT-29 and HCT 116 cells Concentration:0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells)Incubation Time:0, 12, 16, 20, 24, 48, and 72 hours Result:Induced apoptosis in a time-dependent manner.Increased the population of sub-G 1 cells in a time-dependent manner.Western Blot Analysis Cell Line:HT-29 and HCT 116 cells Concentration:0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells)Incubation Time:0, 12, 16, 20, 24, 48, 72, and 96 hours Result: Decreased the amount of cytosolic Ku70 in HCT 116 cells and decreased (0.6-fold) at 48 h and reached the lowest level (0.33-fold) at 96 h.Western Blot Analysis Cell Line:HT-29 and HCT 116 cells Concentration:0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells) Incubation Time:0, 12, 16, 20, 24, 48, and 72 hours Result:Induced the cleavage of caspases and their target proteins.
体内实验

Animal Model:NOD-SCID mice with HT-29 cells xenograftes Dosage:6.2 mg/kg Administration:Oral administration; daily, for 56 days Result:Inhibited tumor growth and decreased tumor weight.
同义词

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通路

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靶点

Other Targets
受体

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研究领域

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适应症

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