4-Hepten-3-one, 7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-, (4E)-

GS-6620 PM is a derivative of GS-6620, an orally administered anti-hepatitis C virus polymerase inhibitor and a novel potent C-nucleoside adenine analogue monophosphate prodrug.GS-6620 has limited activity against other viruses and maintains only partial activity against the closely related bovine viral diarrhea virus (EC50, 1.5 μM).

Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses.