Kushenol A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity.

Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).

Kushenol A (25?μM) exhibits a highly potent inhibitory activity on ABTS+?radical scavenging with an IC50 value of 9.7?±?0.1?μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25?μM.Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC50 value of 57.2 μg/ml for BEAS-2B cells.Cell Viability Assay Cell Line:NSCLC cell lines, A549 and NCI-H226Normal human lung epithelial: BEAS-2B Concentration:0-60 μg/ml Incubation Time:24 hoursResult:Exhibited considerable cytotoxic effects against NSCLC cells.

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Others

Other Targets

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99217-63-7

408.5

C25H28O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (244.80 mM)

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(-20℃)

With Ice Pack

≥ 2 years