Derrone ( —— )

产品货号. M31114 CAS No. 76166-59-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Derrone
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Derrone may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
产品描述

Derrone may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. It is also a novel Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.
体外实验

Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60?μM Derrone, respectively. Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62).Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells.
体内实验

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通路

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Other Targets
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研究领域

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