Spathulenol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway.

Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway; it presents moderate or low cytotoxicity with IC50 higher than 6uM, it is a good candidate to be used in combination chemotherapy of MDR cancer.

Spathulenolexhibits ahigh antioxidant activity s in the DPPH and MDA system,exhibits significant DPPH free radical activity, with IC50 values of85.60 μg/mL.

Spathulenol (oral administration; 300 mg/kg)shows a significant inhibition in the Cg-induced mice paw oedema and pleurisy model.In a spontaneous lipoperoxidation rat brain homogenate model, when incubated in controlled temperature and.oxygenation conditions, PG-1 exhibits a high activity with an IC50 value of 26.13 μg/mL, respectively, which is comparable to a commercial antioxidant BHT (38.41 μg/mL), Thus, PG-1 contributes to a decrease in the generation of MDA,which is a toxic product resulting from the degradation of the cell membrane by lipid peroxidation, causing cell ruptures and mutations.

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Others

Other Targets

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6750-60-3

220.4

C15H24O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (453.82 mM)

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(-20℃)

With Ice Pack

≥ 2 years