SAH-SOS1A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.

SAH-SOS1A (0.625-40 μM) dose-responsively impairs the viability of cancer cells bearing G12D, G12C, G12V, G12S, G13D, and Q61H mutations with IC50 values in the 5- to 15-μM range. Cancer cells expressing wild-type KRAS, such as HeLa and Colo320-HSR cells, are similarly affected.SAH-SOS1A (5-40 μM; 4 hours) dose-responsively inhibits MEK1/2, ERK1/2, and AKT phosphorylation. Cell Viability Assay Cell Line:Panc 10.05 cells bearing the KRAS G12D mutation Concentration:0.625-40 μM Incubation Time:24 hours Result:Dose-responsively impaired the viability of cancer cells bearing KRAS G12D.Western Blot Analysis Cell Line:Panc 10.05 cells Concentration:5-40 μM Incubation Time:Indicated doses for 4 h, followed by 15-min stimulation with EGF Result:Dose-responsively inhibited MEK1/2, ERK1/2, and AKT phosphorylation.

SAH-SOS1A (0.2 μL of 10 mM solution; injection; 48 hours; abdomens of D. melanogaster Ras85DV12/ActinGS) treatment notably decreases the phosphorylation state of ERK1/2.

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MAPK/ERK Signaling

Ras

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1652561-87-9

2187.53

C100H159N27O28

>98% (HPLC)

water:1 mg/mL

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(-20℃)

With Ice Pack

≥ 2 years