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ProTx II
CAS No. 484598-36-9
ProTx II ( —— )
产品货号. M30379 CAS No. 484598-36-9
Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ProTx II
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
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产品描述Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
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体外实验——
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体内实验——
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点Sodium Channel
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受体IC50: 0.3 nM (V1.7), 41 nM (v1.2), 102 nM (V1.3), 39 nM (V1.4), 79 nM (V1.5), 26 nM (V1.6), 146 nM (V1.8)
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研究领域——
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适应症——
化学信息
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CAS Number484598-36-9
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分子量3826.59
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分子式C168H250N46O41S8
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称Sequence:{Tyr}{Cys}{Gln}{Lys}{Trp}{Met}{Trp}{Thr}{Cys}{Asp}{Ser}{Glu}{Arg}{Lys}{Cys}{Cys}{Glu}{Gly}{Met}{Val}(Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
Tanaka K, et al. Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice. J Exp Pharmacol. 2015 Jun 24;7:11-6.
产品手册
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