GsMTx4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor.

GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor.

GsMTx4 (5 μM) reduces Piezo1-mediated charge transfer to 38% of its initial levels in HEK293 cells transfected with Piezo1 cDNA.GsMTx4 (5 μM) blocks cation-selective stretch-activated channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells.GsMTx4 (2.5 μM, 16 h) significantly diminishes both the leptin-induced AMPK and MLC-2 phosphorylation in breast epithelial cells (MCF10A).GsMTx4 (500 nM, 48 h) attenuates demyelination induced by the cytotoxic lipid and psychosine (organotypic cerebellar slices). Western Blot Analysis Cell Line:MCF10A cells Concentration:2.5 μM Incubation Time:16 h Result:Diminished both the leptin-induced AMPK and MLC-2 phosphorylation.

GsMTx4 (stereotactic injection, 3 μM of 1 μL, a single dose) is neuroprotective and inhibits lysophosphatidylcholine-induced astrocyte toxicity and demyelination in the cerebral cortex.GsMTx-4 (intraperitoneal injection, 270 μg/kg for a single dose) reduces mechanical allodynia induced by inflammation and by sciatic nerve injury in Von Frey test. Animal Model:Male C57BL/6 mice (toxin-induced focal demyelination of cortical brain tissue)Dosage:3 μM for 1 μL, a single dose.Administration:Stereotactic injection in the left and right cerebral hemispheres (sacrificed 4 days post-injection)Result:Prevented the enhanced increase in microglial reactivity and microglial cell numbers induced by lysophosphatidylcholine (LPC).Prevented LPC-mediated astrocyte toxicity by attenuating the decrease in GFAP+ cells and GFAP fluorescence intensity.Animal Model:Sciatic nerve injury model of male Sprague-Dawley rats Dosage:270 μg/kg, a single dose Administration:Intraperitoneal injection Result:Reduced inflammation-evoked mechanical allodynia.

——

Membrane Transporter/Ion Channel

TRP/TRPV Channel

MSCs

——

——

1209500-46-8

4101.89

C185H279N49O45S6

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (12.21 mM)

——

Sequence:Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe

(-20℃)

With Ice Pack

≥ 2 years