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Guangxitoxin 1E
CAS No. 1233152-82-3
Guangxitoxin 1E ( —— )
产品货号. M30230 CAS No. 1233152-82-3
Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Guangxitoxin 1E
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.
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产品描述Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials. (In Vitro):Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM. In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner.
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体外实验Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM but has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, nor on calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8, whereas the IC50 for KV4.3 channels is 24-54 nM.In mouse β-cells, Guangxitoxin 1E inhibits 90% of IDR and, as for KV2.1, shifts the voltage dependence of channel activation to more depolarized potentials, a characteristic of gating-modifier peptides. Guangxitoxin 1E broadens theβ-cell action potential, enhances glucose-stimulated intracellular calcium oscillations, and enhances insulin secretion from mouse pancreatic islets in a glucose-dependent manner.
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体内实验——
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同义词——
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体IC50: 1-3 nM (KV2 channels); 24-54 nM (KV4.3 channels)
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研究领域——
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适应症——
化学信息
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CAS Number1233152-82-3
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分子量3948.61
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分子式C178H248N44O45S7
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纯度>98% (HPLC)
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溶解度In Vitro:? H2O : ≥ 1 mg/mL (0.25 mM)
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SMILES——
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化学全称Sequence:{Glu}{Gly}{Glu}{Cys}{Gly}{Gly}{Phe}{Trp}{Trp}{Lys}{Cys}{Gly}{Ser}{Gly}{Lys}{Pro}{Ala}{Cys}{Cys}{Pro}(Disulfide bridge: Cys4-Cys19; Cys11-Cys24; Cys18-Cys31)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
H?nigsperger C, et al. Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. J Physiol. 2017 Feb 1;595(3):739-757.
