Proadrenomedullin (1-20), human ( —— )

产品货号. M30189 CAS No. 150238-87-2

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HNMR

HPLC

MSDS

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产品名称

Proadrenomedullin (1-20), human
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.
产品描述

Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrenal chromaffin cells in vivo. Corresponds to amino acids 1 - 20 of proadrenomedullin. Antihypertensive.
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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CAS Number

150238-87-2
分子量

2460.84
分子式

C112H178N36O27
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

Sequence:{Ala}{Arg}{Leu}{Asp}{Val}{Ala}{Ser}{Glu}{Phe}{Arg}{Lys}{Lys}{Trp}{Asn}{Lys}{Trp}{Ala}{Leu}{Ser}{Arg}-NH2

Mahata M, et al. Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension. 1998 Nov;32(5):907-16.

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