Peptide C105Y ( —— )

产品货号. M30180 CAS No. 247572-63-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Peptide C105Y
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

C105Y, a synthetic peptide (CSIPPEVKFNKPFVYLI) based on the amino acid sequence corresponding to residues 359-374 of alpha1-antitrypsin, enhances gene expression from DNA nanoparticles.
产品描述

C105Y, a synthetic peptide (CSIPPEVKFNKPFVYLI) based on the amino acid sequence corresponding to residues 359-374 of alpha1-antitrypsin, enhances gene expression from DNA nanoparticles.
体外实验

When human hepatoma cells (HuH7) were incubated with fluorescently labeled C105Y for as little as 3 min, C105Y displays nuclear and cytoplasmic staining with enrichment of fluorescent signal in the nucleus and nucleolus. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion, whereas membrane translocation and nuclear localization are energy-independent. When tested the involvement of known endocytosis pathways in uptake and trafficking of this peptide, C105Y peptide is internalized by a clathrin- and caveolin-independent pathway, although lipid raft-mediated endocytosis may play a role in peptide intracellular trafficking.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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CAS Number

247572-63-0
分子量

1994.4
分子式

C97H148N20O23S
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

Sequence:{Cys}{Ser}{Ile}{Pro}{Pro}{Glu}{Val}{Lys}{Phe}{Asn}{Lys}{Pro}{Phe}{Val}{Tyr}{Leu}{Ile}

Rhee M, et al. Mechanism of uptake of C105Y, a novel cell-penetrating peptide. J Biol Chem. 2006 Jan 13;281(2):1233-40.

计算器

产品手册

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