M2N12

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

M2N12 是细胞分裂周期 25C 蛋白磷酸酶 (Cdc25C，IC50 = 0.09 μM) 的有效且高选择性抑制剂。 M2N12 具有抗肿瘤活性。

M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM). M2N12 has anti-tumor activity. M2N12 also has promising activity against Cdc25A(IC50 = 0.53? μM) and Cdc25B(IC50 = 1.39 μM).(In Vitro):M2N12 has cytotoxic activity against five tumor cell lines and a normal cell line including A-549(IC50 = 3.92 μM), MDA-MB-231(IC50 = 4.63 μM), KB(IC50 = 5.05 μM), KB-VIN(IC50 = 6.81 μM), MCF-7(IC50 = 4.71 μM) and HBE(IC50 = 6.00 μM).

M2N12 (0-20 μM; 72 hours) has cytotoxic activity against five tumor cell lines and a normal cell line including A-549, MDA-MB-231, KB, KB-VIN, MCF-7 and HBE (IC50=3.92 μM, 4.63 μM, 5.05 μM, 6.81 μM, 4.71 μM and 6.00 μM, respectively).

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Metabolic Enzyme/Protease

Phosphatase

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2376577-06-7

393.83

C20H16ClN5O2

>98% (HPLC)

In Vitro:?DMSO : 11.11 mg/mL (28.21 mM)

Cc1ccc(Cn2cc(CNC3=C(Cl)C(=O)c4cccnc4C3=O)nn2)cc1

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(-20℃)

With Ice Pack

≥ 2 years