Fz7-21 ( —— )

产品货号. M29962 CAS No. 2247635-23-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Fz7-21
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种有效的 FZD7受体的肽拮抗剂，选择性地结合到 FZD7 CRD 亚类，并改变 CRD 的构象及其脂质结合槽的结构。人和小鼠 FZD7 CRD 的EC50 值分别为 58 和 34 nM。Fz7-21 损害 FZD7 在 Wnt-β-catenin 信号传导中的功能和肠类器官中的干细胞功能。
产品描述

Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100?nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50?nM).
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)
研究领域

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适应症

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计算器

产品手册

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