ARA-290

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种 EPO 衍生物，为特异性的 erythropoietin/CD131 heteroreceptor 的激动剂，常用于神经系统疾病研究。

ARA290 is a nonerythropoietic peptide engineered from erythropoietin,, and used for neurological disease treatment.(In Vitro):ARA290 enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs). ARA290 is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects.(In Vivo):After ECFC transplantation to mice with CLI, a single ARA290 injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4?h after transplantation. ARA290 (30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. ARA290 significantly decreases glucose AUCs in IPGTT in GK rats. Low-dosage ARA290 (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. ARA290-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way.

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Cibinetide

Others

Other Targets

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1208243-50-8

1257.31

C51H84N16O21

>98% (HPLC)

DMSO : ≥ 34 mg/mL (27.04 mM)

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Sequence:{Glp}-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser

(-20℃)

With Ice Pack

≥ 2 years