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Melanin Concentrating Hormone, salmon
CAS No. 87218-84-6
Melanin Concentrating Hormone, salmon ( MCH (salmon) )
产品货号. M29803 CAS No. 87218-84-6
Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7553 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Melanin Concentrating Hormone, salmon
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.
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产品描述Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.(In Vitro):An orphan G protein-coupled receptor (SLC-1/GPR24) has been identified as a receptor for MCH (MCHR1). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein.(In Vivo):Melanin Concentrating Hormone stimulates appetite. Continuous infusion of Melanin Concentrating Hormone into the ventricular system increases food intake for 7-8 days. Intracerebroventricular infusion of Melanin Concentrating Hormone (10 μg/day) causes a slight but significant increase in body weight in mice maintained on the regular diet. Chronic stimulation of the brain Melanin Concentrating Hormone system could cause obesity in mice.
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体外实验An orphan G protein-coupled receptor (SLC-1/GPR24) has been identified as a receptor for MCH (MCHR1). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein.
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体内实验Melanin Concentrating Hormone stimulates appetite. Continuous infusion of Melanin Concentrating Hormone into the ventricular system increases food intake for 7-8 days. Intracerebroventricular infusion of Melanin Concentrating Hormone (10 μg/day) causes a slight but significant increase in body weight in mice maintained on the regular diet. Chronic stimulation of the brain Melanin Concentrating Hormone system could cause obesity in mice.
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同义词MCH (salmon)
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通路Others
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靶点Other Targets
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受体SLC-1/GPR24, MCHR2
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研究领域——
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适应症——
化学信息
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CAS Number87218-84-6
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分子量2099.48
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分子式C89H139N27O24S4
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称Sequence:Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val (Disulfide bridge: Cys5-Cys14)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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SLC26A3-IN-1
SLC26A3-IN-1 是一种阴离子交换蛋白 SLC26A3 的抑制剂 (IC50=340 nM)。SLC26A3 属于溶质载体 (SLC) 蛋白，属于 SLC26 家族。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调，参与氯化物和草酸盐的肠道吸收。SLC26A3 功能突变的丧失与氯离子丢失性腹泻有关。
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Sodium Hydrogen Sulf...
Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sulfide (hydrate) is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration, reduces airway inflammation, and protects neurites, heart, and intestine from chemical or ischemic-reperfusion damage.
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NNC 63-0532
NOP受体激动剂。
