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TAK-448
CAS No. 1234319-68-6
TAK-448 ( MVT-602 )
产品货号. M29793 CAS No. 1234319-68-6
TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3876 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TAK-448
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
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产品描述TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.(In Vivo):TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model.
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体外实验——
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体内实验TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model. Animal Model:Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)Dosage:0.01, 0.03, 0.3, 3 mg/kg Administration:Given i.h.; dosings on day 0 and 28 Result:Had greater anti-tumor effects in VCaP xenograft model.
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同义词MVT-602
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通路Others
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靶点Other Targets
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受体IC50: 460 pM (KISS1R)
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研究领域——
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适应症——
化学信息
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CAS Number1234319-68-6
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分子量1225.36
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分子式C58H80N16O14
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称Sequence:Ac-D-Tyr-D-Trp-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly PotentTestosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811.
