BI-2865 ( —— )

产品货号. M29653 CAS No. 2937327-93-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BI-2865
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively.
产品描述

BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM).BI-2865 is a derivative with a prolinol substituent and a pyrimidine linker. BI-2865 has direct ionic interaction with E62, and a water-mediated hydrogen bond network with the side chain of R68 and the main chain carbonyl of Q61, as shown in Co-crystal structures of BI-2865 bound to KRAS.BI-2865 (5 days) inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells in the presence of IL-13, with a mean IC50 of roughly 140?nM.
体外实验

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体内实验

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同义词

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通路

MAPK/ERK Signaling
靶点

p38 MAPK
受体

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研究领域

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适应症

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CAS Number

2937327-93-8
分子量

465.57
分子式

C23H27N7O2S
纯度

>98% (HPLC)
溶解度

DMSO : 250 mg/mL (536.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
SMILES

N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(O[C@@H](C)[C@@H]5CCCN5C)=CC=N4)=NO3)CCC2
化学全称

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