Azaserine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Azaserine 是一种从链霉菌属中分离出来的肿瘤抑制抗生素，具有谷氨酰胺酰胺转移酶抑制剂的作用。

Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.(In Vitro):Azaserine inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins . Azaserine (25 μM) inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase, and glucosamine-6-phosphate isomerase.

Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells.Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049.

Azaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats. Animal Model:Wistar rats Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month Result:After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.

CI-337 | O-Diazoacetyl-L-serine | P-165

Others

Other Targets

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115-02-6

173.128

C5H7N3O4

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (288.80 mM)

N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years