Homobutein

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Homobutein 是 HDAC 和 NF-κB 的双重抑制剂，IC50 分别为 190 和 38 μM。 Homobutein 是一种铁螯合剂，具有抗癌、抗炎、抗寄生虫和抗氧化活性。

Homobutein is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.(In Vitro):Homobutein (1 μg/mL) inhibits the growth of Toxoplasma gondii by 19.48% with IC50s of 15.0 and 16.1 μM for W2 and D6 strains of P. falciparum. Homobutein (20 - 40 μM) inhibits the viability and TNFα-induced NF-κB activity of K562 cells.

Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells.Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells.Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%.Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 μM, respectively.Cell Viability Assay Cell Line:K562 cells Concentration:20, 24, 28, 32, 40 μM Incubation Time:2 h Result:Showed inhibition of viability in K562 cells.Cell Viability AssayCell Line:Toxoplasma gondii RH-2F strain Concentration:1 μg/mL Incubation Time:72 h Result:Surpressed 19.48% of the Toxoplasma gondii.

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2',4,4'-Trihydroxy-3-methoxychalcone | 3-O-Methylbutein

Others

Antioxidant

Antioxidant

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34000-39-0

286.28

C16H14O5

>98% (HPLC)

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C(=C/C(=O)C1=C(O)C=C(O)C=C1)\C2=CC(OC)=C(O)C=C2

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(-20℃)

With Ice Pack

≥ 2 years