3',4'-Dimethoxyflavone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3',4'-二甲氧基黄酮是黄酮类化合物的标准化合物，具有多种药用活性。

3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.

3',4'-Dimethoxyflavone (10 and 20 μM) has protection against the reduction in SH-SY5Y viability induced by Methylnitronitrosoguanidine(MNNG) (HY-128612).3',4'-Dimethoxyflavone (6.25-25 μM) decreases the levels of PAR induced by MNNG in HeLa cells.3',4'-Dimethoxyflavone (12.5, 25, 50 and 100 μM; 15-20 h) reduces cortical neuronal death induced by exposure to NMDA (HY-17551).3',4'-Dimethoxyflavone (0.1-10 μM; 24 h) exhibits significant inhibition of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced EROD activity in MCF-7 and T47D cells.3',4'-Dimethoxyflavone inhibits AhR-dependent CYP1A1 induction and AhR-mediated inhibition of estrogen-induced gene expression in T47D and MCF-7 breast cancer cells.3′,4′-Dimethoxyflavone (2.5 μM; 7 days) promotes the proliferation of human hematopoietic stem cells. Cell Viability Assay Cell Line:Primary cortical neurones (isolated from fetal CD1 mice, incubated with NMDA)Concentration:12.5, 25, 50 and 100 μM Incubation Time:15-20 h Result:Reduced concentration-dependently neuronal death induced by exposure to NMDA.Cell Proliferation Assay Cell Line:CD34+ cells Concentration:2.5 μM Incubation Time:7 days Result:Induced a significantly higher amplification of the CD34+ population under normoxia.

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Others

Other Targets

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4143-62-8

282.295

C17H14O4

>98% (HPLC)

In Vitro:?DMSO : ≥ 50 mg/mL (177.12 mM)

COc1ccc(cc1OC)-c1cc(=O)c2ccccc2o1

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(-20℃)

With Ice Pack

≥ 2 years