Tigloylgomisin H

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tigloylgomisin H 显着诱导 Hepa1c1c7 小鼠肝癌细胞中醌还原酶 (QR) 活性。

Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies.(In Vitro):Tigloylgomisin H (TGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) of 10.80 as compared to control. Tigloylgomisin H also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, Tigloylgomisin H significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.

——

——

——

Nuclear Receptor/Transcription Factor

Keap1-Nrf2

Nrf2

——

——

66069-55-4

500.59

C28H36O8

>98% (HPLC)

——

COc1cc2C[C@H](C)[C@@](C)(O)Cc3cc(OC)c(OC)c(OC)c3-c2c(OC(=O)C(\C)=C\C)c1OC

——

(-20℃)

With Ice Pack

≥ 2 years