Ganoderic acid H

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

灵芝酸H是一种有效的抗肿瘤剂，它通过抑制转录因子AP-1和NF-κB，从而抑制uPA的分泌来介导其生物学效应。

Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-κB, resulting in the suppression of secretion of uPA.(In Vitro):In highly invasive human breast cancer cells, Ganoderic acid H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells. Furthermore, the activity of Ganoderic acid H is linked to the hydroxylation in the positions 7 and 3 in its triterpene lanostane structure. Ganoderic acid H could be a promising natural agent for the therapy of invasive breast cancers.

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Apoptosis

NF-κB

NF-κB

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98665-19-1

572.695

C32H44O9

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (174.61 mM)

[H][C@@]12CC(=O)C3=C(C(=O)[C@@H](OC(C)=O)[C@]4(C)[C@H](CC(=O)[C@@]34C)[C@H](C)CC(=O)CC(C)C(O)=O)[C@@]1(C)CC[C@H](O)C2(C)C

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(-20℃)

With Ice Pack

≥ 2 years