Caulilexin C

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Caulilexin C 在 100 μg/ml 浓度下对人酰基辅酶 A：胆固醇转移酶 I (hACATI) 和人酰基辅酶 A：胆固醇转移酶 2 (hACAT2) 显示抑制活性。

Caulilexin C shows inhibitory activity on human Acyl CoA: cholesterol transferase I (hACATI) and on human Acyl CoA: cholesterol transferase 2 (hACAT2) at 100 mug/ml.(In Vitro):Toward this end, the metabolism of indolyl glucosinolates, their corresponding desulfo-derivatives, and derived metabolites, by three fungal species pathogenic on crucifers was investigated. While glucobrassicin, 1-methoxyglucobrassicin, 4-methoxyglucobrassicin were not metabolized by the pathogenic fungi Alternaria brassicicola, Rhizoctonia solani and Sclerotinia sclerotiorum, the corresponding desulfo-derivatives were metabolized to indolyl-3-acetonitrile, Caulilexin C (1-methoxyindolyl-3-acetonitrile) and arvelexin (4-methoxyindolyl-3-acetonitrile) by R. solani and S. sclerotiorum, but not by A. brassicicola. That is, desulfo-glucosinolates were metabolized by two non-host-selective pathogens, but not by a host-selective. Indolyl-3-acetonitrile, Caulilexin C and arvelexin were metabolized to the corresponding indole-3-carboxylic acids. Indolyl-3-acetonitriles displayed higher inhibitory activity than indole desulfo-glucosinolates. Indolyl-3-methanol displayed antifungal activity and was metabolized by A. brassicicola and R. solani to the less antifungal compounds indole-3-carboxaldehyde and indole-3-carboxylic acid.

Caulilexin C causes complete growth inhibition (0.5 mM) of Rhizoctonia solani and has a smaller effect on Leptosphaeria maculans (77% inhibition), appearing to be slightly more antifungal than arvelexin.

——

——

Others

Other Targets

——

——

——

30536-48-2

186.214

C11H10N2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (537.03 mM)

COn1cc(CC#N)c2ccccc12

——

(-20℃)

With Ice Pack

≥ 2 years