Galloylpaeoniflorin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Galloylpaeoniflorin 可开发为对抗 ROS 介导的氧化应激的细胞保护剂。 Galloylpaeoniflorin 也是 NF-κB 和 DNA 裂解的抑制剂。

Galloylpaeoniflorin may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibtior of NF-κB and DNA cleavage.(In Vitro):Galloylpaeoniflorin demonstrated a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 (-)), and the hydroxyl radical (?OH). Galloylpaeoniflorin also safeguarded HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins. Galloylpaeoniflorin exerted its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species.

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6'-O-Galloyl paeoniflorin

Apoptosis

NF-κB

NF-κB

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122965-41-7

632.571

C30H32O15

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (158.09 mM)

C[C@@]12C[C@@]3(O)O[C@@H](O1)[C@]1(COC(=O)c4ccccc4)[C@H]3C[C@]21O[C@@H]1O[C@H](COC(=O)c2cc(O)c(O)c(O)c2)[C@@H](O)[C@H](O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years