UCM-1336

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UCM-1336 是一种有效的 ICMT 抑制剂，IC50 为 2 μM，对参与 Ras 翻译后修饰的其他酶具有选择性。

UCM-1336 is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in the post-translational modifications of Ras.(In Vitro):UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. UCM-1336 induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. Because ICMT inhibition impairs the activity of the four Ras isoforms regardless of its activating mutation, UCM-1336 surmounts many of the common limitations of available Ras inhibitors described so far.(In Vivo):UCM-1336 significantly inhibits glioblastoma growth without causing toxicity in mice.

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3,3′-(Octylimino)bis[N-phenylpropanamide]

Others

Other Targets

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1621535-90-7

423.59

C26H37N3O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (236.08 mM)

CCCCCCCCN(CCC(Nc1ccccc1)=O)CCC(Nc1ccccc1)=O

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(-20℃)

With Ice Pack

≥ 2 years