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PARP1-IN-8?
CAS No. 836640-15-4
PARP1-IN-8? ( N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide )
产品货号. M28956 CAS No. 836640-15-4
PARP1-IN-8 是 PARP1 的有效抑制剂 (IC50 = 97 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1359 | 有现货 |
|
| 10MG | ￥2195 | 有现货 |
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| 25MG | ￥3450 | 有现货 |
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| 50MG | ￥4752 | 有现货 |
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| 100MG | ￥6102 | 有现货 |
|
| 200MG | ￥8253 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PARP1-IN-8?
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PARP1-IN-8 是 PARP1 的有效抑制剂 (IC50 = 97 nM)。
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产品描述PARP1-IN-8 is an effective inhibito of PARP1 (IC50 = 97 nM).(In Vitro):PARP1-IN-8 (0, 0.1, 1, 10 μM; 24, 48 h) showed significantly potent anti-proliferative activity against A549 cells and didn’t display any significant cytotoxicity on HFF cells.
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体外实验PARP1-IN-8 (compound 11c) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells. Cell Proliferation Assay Cell Line:A549, HFF cells Concentration:0, 0.1, 1, 10 μM Incubation Time:24, 48 h Result:Showed significantly potent anti-proliferative activity against A549 cells, and didn’t display any significant cytotoxicity on HFF cells.
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体内实验——
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同义词N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide
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通路Cell Cycle/DNA Damage
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靶点PARP
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受体BRD4
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研究领域——
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适应症——
化学信息
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CAS Number836640-15-4
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分子量403.87
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分子式C23H18ClN3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 62.5 mg/mL (154.76 mM)
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SMILESClc1cccc(NC(=O)CCn2nc(-c3ccccc3)c3ccccc3c2=O)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957.
