ZINC05007751

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ZINC05007751 是 NIMA 相关激酶 NEK6 的有效抑制剂 (IC50 = 3.4 μM)。 ZINC05007751 对 NEK1 和 NEK6 具有很强的选择性，但对 NEK2、NEK7 和 NEK9 没有观察到显着的活性。

ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.(In Vitro):In ovarian cancer cells PEO1, ZINC05007751 induced perturbation of the cell cycle. ZINC05007751 showed synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1??μM, with a combination of ZINC05007751 (44?μM)?+?Cisplatin (10?μM) exhibiting the greatest synergistic effect. ZINC05007751 (6 μM-190 μM; 24 hours) inhibited the growth of MDA-MB-231, PEO1, NCI-H1299, and HCT-15 with IC50 below 100?μM.

ZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100?μM.ZINC05007751 induces perturbation of PEO1 cell cycle.ZINC05007751 (ovarian cancer cells PEO1) shows synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1??μM, with combination ZINC05007751 (44?μM)?+?Cisplatin (10?μM) exhibiting the greatest synergistic effect. Cell Cytotoxicity Assay Cell Line:MDA-MB-231, PEO1, NCI-H1299 and HCT-15 cells Concentration:6 μM-190 μM Incubation Time:24?hours Result:Inhibited the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15.

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MAPK/ERK Signaling

p38 MAPK

ATX (autotaxin)

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591239-68-8

304.305

C18H12N2O3

>98% (HPLC)

In Vitro:?DMSO : 8.33 mg/mL (27.37 mM)

CC1=C(C#N)C(O)=NC(=O)\C1=C/c1ccc(o1)-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years