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TRPM4 inhibitor 8
CAS No. 1353979-43-7
TRPM4 inhibitor 8 ( —— )
产品货号. M28894 CAS No. 1353979-43-7
TRPM4 抑制剂 8 是一种瞬时受体电位 melastatin 4 (TRPM4) 的抑制剂，它有助于活力、迁移、细胞周期转变和粘附。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥278 | 有现货 |
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| 10MG | ￥411 | 有现货 |
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| 25MG | ￥631 | 有现货 |
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| 50MG | ￥1228 | 有现货 |
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| 100MG | ￥1782 | 有现货 |
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| 200MG | ￥2808 | 有现货 |
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| 500MG | ￥4644 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥306 | 有现货 |
|
生物学信息
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产品名称TRPM4 inhibitor 8
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TRPM4 抑制剂 8 是一种瞬时受体电位 melastatin 4 (TRPM4) 的抑制剂，它有助于活力、迁移、细胞周期转变和粘附。
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产品描述TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
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体外实验NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner.NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs.
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体内实验——
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点TRP/TRPV Channel
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受体Endothelin A receptor|Endothelin B receptor
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研究领域——
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适应症——
化学信息
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CAS Number1353979-43-7
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分子量257.175
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分子式C11H17BrN2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (388.85 mM)
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SMILESCCN(CCN)Cc1cccc(Br)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Balwierczak JL, et al. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6.
