TBAP-001

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TBAP-001 是一种 RAF 激酶抑制剂，在 BRAF V600E 激酶测定中的 IC50 为 62 nM，在基于细胞的 Phosho-ERK 测定中的 IC50 为 18 nM。

TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.(In Vitro):The IC50 values of TBAP-001 are 178 nM (A375), 62 nM (WM266.4), 72 nM (UACC62), 93 nM (LOX INVI), 590 nM (HT 29), 43 nM (COLO225), 690 nM (RKO), 490 nM (Mawi), 390 nM (WiDr), 480 nM (Colo741), 480 nM (SW620), 600 nM (HCT116), 390 nM (SKMEL2), 710 nM (D04), 390 nM (WM1361), 1150 nM (PDAC R172H (p53 mut)), 290 nM (MiaPaCa) and 490nM (RPMI8226) in different cancer cell lines.

BAP-001 (Synthesis 13) exhibits IC50 values of 178 nM (A375), 62 nM (WM266.4), 72 nM (UACC62), 93 nM (LOX INVI), 590 nM (HT 29), 43 nM (COLO225), 690 nM (RKO), 490 nM (Mawi), 390 nM (WiDr), 480 nM (Colo741), 480 nM (SW620), 600 nM (HCT116), 390 nM (SKMEL2), 710 nM (D04), 390 nM (WM1361), 1150 nM (PDAC R172H (p53 mut)), 290 nM (MiaPaCa) and 490nM (RPMI8226) in different cancer cell lines.

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MAPK/ERK Signaling

Raf

Mps1|TTK

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1777832-90-2

531.51

C27H23F2N7O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (470.36 mM)

CC(C)(C)c(cc1NC(Nc(ccc(Oc(ccnc2N3)c2N=CC3=O)c2)c2F)=O)nn1-c1cc(F)ccc1

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(-20℃)

With Ice Pack

≥ 2 years