OATD-01

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

OATD-01 是一种高活性的 Chitotriosidase (CHIT1) 和酸性哺乳动物几丁质酶 (AMCase) 抑制剂。

OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).(In Vitro):The Ki values for hCHIT1,mCHIT1, hAMCase and mAMCase are 17.3 nM, 26.05 nM, 4.8 nM and 5.7 nM, respectively. These Ki values reveals good correlation with earlier established IC50 data, which are 23 nM, 28 nM, 9 nM and 7.8 nM, respectively. OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets.(In Vivo):OATD-01 given orally once daily in a range of doses between 30 and 100 mg/kg showed significant antifibrotic efficacy in an animal model of bleomycin-induced pulmonary fibrosis.

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Animal Model:Female BALB/c mice Dosage:30 mg/kg, 100 mg/kg Administration:Oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days Result:Reduced the degree of lung fibrosis in vivo.

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Others

Other Targets

PDE3A

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2088453-21-6

390.91

C19H27ClN6O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (255.81 mM)

C[C@@H](C1)OC[C@H](Cc(cc2)ccc2Cl)N1C(CC1)CCN1c1nc(N)n[nH]1

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(-20℃)

With Ice Pack

≥ 2 years