MRTX9768

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MRTX-9768 是一种合成的致死抑制剂，旨在结合 PRMT5-MTA 复合物并选择性靶向 MTAP/CDKN2A 缺失的肿瘤。

MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.(In Vitro):MRTX-9768, a potent inhibitor of SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM).(In Vivo):In xenograft studies, oral administration of MRTX-9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow.

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MRTX-9768 | MRTX9768

Chromatin/Epigenetic

Histone Demethylase

CK2

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2629314-68-5

424.43

C24H17FN6O

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (117.81 mM)

FC1=C(C2=C(C3=CC=C(C(NN=C4CN)=O)C4=C3)C=NN2C)C(C#N)=C(C=CC=C5)C5=C1

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(-20℃)

With Ice Pack

≥ 2 years