ARN19702

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ARN19702 是一种选择性、口服活性、可逆性、脑渗透性 N-酰基乙醇胺酸酰胺酶 (NAAA) 抑制剂，对人 NAAA 的 IC50 为 230 nM。 ARN19702 具有缓解疼痛的作用。

ARN19702 is a selective, orally active, reversible, and brain-penetrant?N-acylethanolamine acid amidase (NAAA)?inhibitor with an?IC50?of 230 nM for?human NAAA. ARN19702 has pain relief effects.(In Vivo):In male mice, administration of ARN19702 (3-10 mg/kg; p.o.) daily for 7 consecutive days decreases nociception associated with Paclitaxel-induced neuropathy without the development of subacute antinociceptive tolerance. Administration of ARN19702 (0.1-30 mg/kg; p.o.) attenuates dose-dependently the spontaneous nocifensive response elicited by intraplantar formalin injection and the hypersensitivity caused by intraplantar carrageenan injection, paw incision, or sciatic nerve ligation. Administration of ARN19702 (3-10 mg/kg; p.o.) also produces remarkable protective effects against multiple sclerosis in mice.

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ARN19702 (3-10 mg/kg; po; daily; for 7 consecutive days) reduces nociception associated with Paclitaxel-induced neuropathy without development of subacute antinociceptive tolerance in male rats. In male mice, ARN19702 (0.1-30 mg/kg; po) attenuates in a dose-dependent manner the spontaneous nocifensive response elicited by intraplantar formalin injection and the hypersensitivity caused by intraplantar carrageenan injection, paw incision, or sciatic nerve ligation.. ARN19702 (3-10 mg/kg; po) produces remarkable protective effects against multiple sclerosis in mice.

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Others

Other Targets

DHODH

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1971937-18-4

447.54

C21H22FN3O3S2

>98% (HPLC)

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CCS(=O)(=O)c1ccccc1C(=O)N1CCN(C[C@@H]1C)c1nc2ccc(F)cc2s1

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(-20℃)

With Ice Pack

≥ 2 years