Inarigivir ammonium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Inarigivir 铵是一种二核苷酸抗病毒化合物，可显着降低表达乙型肝炎病毒的转基因小鼠中的 HBV DNA。 Inarigivir 是一种视黄酸诱导基因-I (RIG-I) 的激动剂，可激活细胞内先天免疫。

Inarigivir ammonium is a dinucleotide antiviral compound that significantly reduces HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir is an agonist of retinoic acid-inducible gene-I (RIG-I) that activates intracellular innate immunity.(In Vitro):Inarigivir is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B.(In Vivo):Administration of 100 mg/kg/day Inarigivir (ip) significantly reduces viral DNA in the liver and shows anti-HBV activity while serum HBV DNA is not reduced. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values.

Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B.

Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values. Animal Model:Mice Dosage:100 mg/kg.Administration:IP, daily.Result:Significantly reduced viral DNA in the liver and shows anti-HBV activity similar ADV positive control.

ORI-9020 ammonium | SB-9200 ammonium

Microbiology/Virology

HBV

HIF/HIF Prolyl-Hydroxylase

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2172788-92-8

604.53

C20H29N8O10PS

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (165.42 mM)

NC1=C(N=CN2[C@@H]3O[C@H](COP(O[C@H]4[C@@H](OC)[C@H](N5C=CC(NC5=O)=O)O[C@@H]4CO)(S)=O)[C@@H](O)C3)C2=NC=N1.N

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(-20℃)

With Ice Pack

≥ 2 years