Mesdopetam hemitartrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mesdopetam hemitartrate 是多巴胺 D3 受体的拮抗剂（Ki=90 nM；对于人重组 D3 受体，IC50=9.8 μM）。

Mesdopetam hemitartrate is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor). It has psychomotor stabilizing properties.

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Mesdopetam (IRL790) (3.7, 11, 33, or 100 μmol/kg; s.c.) hemitartrate dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80. Animal Model:Male Sprague-Dawley ratsDosage:3.7, 11, 33, or 100 μmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl) Administration:s.c. was administered subcutaneously 4 min before the start of recording Result:Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.

1-?Propanamine, N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (2:1) | IRL790 hemitartrate

GPCR/G Protein

Dopamine Receptor

p38α

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2562346-14-7

700.77

C28H42F2N2O12S2

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (142.70 mM)

CCCNCCOC1=CC(S(=O)(C)=O)=CC(F)=C1.CCCNCCOC2=CC(S(=O)(C)=O)=CC(F)=C2.O=C(O)[C@H](O)[C@@H](O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years