Rasarfin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Rasarfin 抑制 Ras 和 ARF6。

Rasarfin inhibits Ras and ARF6.(In Vitro):Rasarfin resulted in a dose-dependent reduction in cell growth in MDA-MB-231 cells.After 48 and 72?h of treatment, Rasarfin modestly decreased in a dose-dependent manner the metabolic activity of cancer cells compared to cells treated with DMSO.However, compared to Doxorubicin which potently killed cells, cell viability was not affected by Rasarfin treatment. Rasarfin inhibited proliferation of A549 lung cancer cells, which have increased Ras and EGFR activity52. Similar to the anti-proliferative effect on MDA-MB-231 cells, A549 cell growth inhibition at 5 and 10?μM of Rasarfin,more important cell viability effects of Rasarfin on A549 cells than MDA-MB-231 cells at 10?μM of Rasarfin treatment.

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Others

Other Targets

EGFR

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674359-73-0

425.91

C23H24ClN3O3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (117.40 mM)

CC(C)C(N(CC1)CCN1c(ccc(NC(c1cc(cccc2)c2o1)=O)c1)c1Cl)=O

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(-20℃)

With Ice Pack

≥ 2 years