Thalidomide-NH-PEG1-NH2 hydrochloride ( 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl )

产品货号. M28662 CAS No. 2154342-56-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Thalidomide-NH-PEG1-NH2 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

沙利度胺-NH-PEG1-NH2 盐酸盐是一种合成的 E3 连接酶配体-连接子缀合物，包含基于沙利度胺的 cereblon 配体和连接子。
产品描述

Thalidomide-NH-PEG1-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker.
体外实验

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
体内实验

——
同义词

4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
通路

Others
靶点

Other Targets
受体

TGFβRI
研究领域

——
适应症

——

1.Flavia Mercer Pernasetti, et al. Combinations of tgfb inhibitors and cdk inhibitors for the treatment of breast cancer. Patent WO2020058820A1.

计算器

产品手册

关联产品

Silyamandin

Silyamandin may have antihepatotoxic and chemopreventive activities.
Ibuprofen Piconol

Ibuprofen piconol 是一种非甾体类抗炎 (NSAID) 剂，用于局部缓解原发性热烧伤和晒伤。Ibuprofen piconol 是布洛芬的吡啶酯。
Cortistatin-29 (rat)

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.