DSRM-3716

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Isoquinoline, 5-iodo- (9CI) 是一种有效的选择性 SARM1 抑制剂 (IC50 = 75 nM)，可防止轴突变性并允许受损但存活的轴突亚稳态池的功能恢复。

Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.(In Vitro):Treatment with the isoquinoline Isoquinoline, 5-iodo- (9CI) produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. Isoquinoline, 5-iodo- (9CI) prevented NfL release from severed axons in a dose-dependent manner.

DSRM-3716 treatment produces dose-dependent inhibition of cADPR increase (IC50 of 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. DSRM-3716 prevents neurofilament light chain (NfL) release from severed axons in a dose-dependent manner, with an IC50 of ~2 μM.The potency of DSRM-3716 to inhibit cADPR increase caused by axotomy (IC50 of 2.8 μM) is similar to the potency required to prevent axonal degeneration (IC50 of 2.1 μM).DSRM-3716 inhibits the SARM1-dependent cell destruction pathway triggered by Rotenone in sensory neurons.

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5-Iodoisoquinoline

Endocrinology/Hormones

Androgen Receptor (AR)

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58142-99-7

255.06

C9H6IN

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (196.03 mM)

Ic1cccc2cnccc12

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(-20℃)

With Ice Pack

≥ 2 years