(S,R,S)-AHPC-Me

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(S,R,S)-AHPC-Me（VHL 配体 2）是基于 (S,R,S)-AHPC 的 VHL 配体，用于招募 von Hippel-Lindau (VHL) 蛋白。 (S,R,S)-AHPC-Me可用于合成ARV-771。

(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

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VHL ligand 2 | E3 ligase Ligand 1A

Others

Other Targets

α1A-adrenergic receptor

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1948273-02-6

444.59

C23H32N4O3S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (562.32 mM)

C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C

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(-20℃)

With Ice Pack

≥ 2 years