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Enpp-1-IN-14
CAS No. 2687222-59-7
Enpp-1-IN-14 ( —— )
产品货号. M28549 CAS No. 2687222-59-7
ENPP1-IN-2 是外核苷酸焦磷酸酶/磷酸二酯酶-1 (ENPP1) 的有效抑制剂，对重组人 ENPP-1 的 IC50 值为 32.38 nM。 ENPP1-IN-2 具有抗肿瘤活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1169 | 有现货 |
|
| 10MG | ￥1881 | 有现货 |
|
| 25MG | ￥3134 | 有现货 |
|
| 50MG | ￥4548 | 有现货 |
|
| 100MG | ￥6174 | 有现货 |
|
| 200MG | ￥8325 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Enpp-1-IN-14
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ENPP1-IN-2 是外核苷酸焦磷酸酶/磷酸二酯酶-1 (ENPP1) 的有效抑制剂，对重组人 ENPP-1 的 IC50 值为 32.38 nM。 ENPP1-IN-2 具有抗肿瘤活性。
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产品描述ENPP1-IN-2 is a potent inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.(In Vivo):ENPP1-IN-2 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth in Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells).
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体外实验——
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体内实验Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth. Animal Model:Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)Dosage:50 mg/kg Administration:IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)Result:Significantly inhibited tumor growth.
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同义词——
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通路Angiogenesis
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靶点PDE
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受体KSP
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研究领域——
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适应症——
化学信息
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CAS Number2687222-59-7
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分子量403.88
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分子式C15H22ClN5O4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 9.62 mg/mL (23.82 mM)
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SMILESCl.O=S(=O)(N)N1CCN(C=2N=CN=C3C=C(OC)C(OC)=CC32)CCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Woessner R, et al. ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 2009 Nov;29(11):4373-80.
产品手册
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