TMPH

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TMPH 是 nAChR 的抑制剂，可抑制缺乏 α5、α6 或 β3 亚基的 nAChR。 TMPH 可用于 nAChR 功能障碍或神经系统疾病的研究。

TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.(In Vitro):TMPH (100 nM) inhibits nAChR with an inhibition rate of 90% in Xenopus oocytes and suppresses AChR subtypes with IC50s of 1.0-390 nM.(In Vivo):In the nicotine-induced mice model, nAChR-IN-1 (20 mg/kg; s.c.) increases locomotor activity without effects on body temperature. In the tail-flick and hot-plate mice model, nAChR-IN-1(0, 0.1, 1, 5 mg/kg; s.c.) blocks the antinociceptive effect of nicotine in the hot-plate and blocks antinociception in a time-dependent manner.

nAChR-IN-1 (100 nM) inhibits nAChR with inhibition rate of 90% in Xenovus oocytes, and suppresses AChR subtypes (mouse muscle-type (α1β1εδ) nAChR, three different pairwise combinations of rat neuronal alpha and beta subunits (α3β4, α4β2, and α3β2), and α7 homomeric neuronal nAChR) with IC50s (area) of 390, 1.2, 110, 75, 440, 460, 430, 2.7, 1.0, 1.4, and 18.3 nM, respectively, based on the decrease in the net charge of the ACh response.

nAChR-IN-1 (20 mg/kg; s.c.; single dose) improves nicotine-induced hypomotility and hypothermia in a time-dependent manner in mice. Animal Model:Nicotine-induced mice model Dosage:20 mg/kg Administration:Subcutaneous injection; single dose; 15 minutes prior to the injection of nicotine (1.5 mg/kg)?Result:Increased locomotor activity in mice, even if nicotine-induced decrease.Showed no effect on body temperature.Animal Model:Tail-flick and hot-platemodel in miceDosage:0, 0.1, 1, 5 mg/kg Administration:Subcutaneous injection; single dose Result:Blocked the antinociceptive effect of nicotine in the hot-plate.Time-dependently blocked nicotine-induced antinociception.

2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Cell Cycle/DNA Damage

AChR

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849461-90-1

269.42

C16H31NO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (371.17 mM)

O=C(OC1CC(NC(C)(C)C1)(C)C)CCCCCC

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(-20℃)

With Ice Pack

≥ 2 years