NPT200-11

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NPT200-11 是一种口服生物可利用的脑穿透抑制剂，可抑制 α-突触核蛋白 (ASYN) 错误折叠和聚集的积累。

NPT200-11 is an orally bioavailable and brain penetrating inhibitor of accumulation of alpha-synuclein (ASYN) misfolding and aggregation. NPT200-11 can be used in studies about the underlying pathology of synucleinopathies including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Multiple Systems Atrophy (MSA).(In Vivo):In the Line 61 transgenic mouse model overexpressing human wild type ASYN, NPT200-11 (5 mg/kg; i.p.) results in a time-dependent and progressive reduction in retinal ASYN pathology. NPT200-11 reduced alpha-synuclein pathology in cortex, reduced associated neuroinflammation (astrogliosis), normalized striatal levels of the dopamine transporter (DAT) and improved motor function.

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Others

Other Targets

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2227057-23-8

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years