AC1-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AC1-IN-1 是 1 型腺苷酸环化酶的选择性抑制剂 (AC1, IC50 = 0.54 μM)。

AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 μM).(In Vitro):In HEK293 cells, AC1-IN-1 (30 μM, 1 hours) shows nontoxic to this human cell line.(In Vivo):AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min time point.

AC1-IN-1 (compound 38; HEK293 cells; 30 μM, 1 hours) shows nontoxic to this human cell line.Cell Cytotoxicity Assay Cell Line:HEK293 cells Concentration:30 μM Incubation Time:1 hours Result:Showed nontoxic to HEK293 cells.

AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point. Animal Model:Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)Dosage:5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)Administration:Intravenous injection; 2 hours Result:Displayed modest, yet statistically significant, antiallodynic effects.

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Others

Other Targets

Apoptosis inhibitor

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2762422-55-7

355.37

C18H18FN5O2

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (70.35 mM)

CCC1=CC(=O)N=C(N2N=C(C)C=C2NC(=O)C2=C(F)C=CC(C)=C2)N1

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(-20℃)

With Ice Pack

≥ 2 years