Sertaconazole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

舍他康唑是一种广谱抗真菌药。

Sertaconazole is a broad-spectrum antifungal.

Sertaconazole (0.03-40 μg/mL; 24 h) inhibits 150 strains of yeasts which includes six Candida species with arithmetic mean MIC of 0.77 μg/mL.Sertaconazole (1 μg/mL; 5, 10, 30, 60 min) activates p38 MAP kinase in a time-dependent manner.Sertaconazole (1, 2 μg/mL; 6, 8, or 24 h) increases a twofold release of PGE2 via COX-2 in keratinocytes, which is dependent on p38 activation.Cetaconazole (10, 20, 30, 40 μM; 24 h) induces strong mitotic arrest by depolymerizing interphase and spindle microtubules, thereby inducing chromosome aggregation defects and causing anti-proliferation effect.Sertaconazole (20, 40 μM; 24 h) induces apoptosis through p53 pathway in HeLa cells.Sertaconazole (20, 30 μM; 24, 48, and 72 h) inhibits the migration of HeLa cells in a concentration-dependent manner.Sertaconazole (15, 30 μM; 24 h) induces autophagy in A549, H460 cells. Cell Viability AssayCell Line:C. albicans, C. guilliermondii, C. krusei, C. parapsilosi, C. tropicalis, C. glabrataConcentration:0.03-40 μg/m Incubation Time:24 h Result:Againsted 150 strains of yeasts (six Candida species) which included C. albicans, C. guilliermondii, C. krusei, C. parapsilosi, C. tropicalis, C. glabrata species with arithmetic mean MIC values of 1.02, 0.51, 0.38, 0.31, 1.67 and 0.78 μg/mL, respectively.Western Blot Analysis Cell Line:HaCaT cells Concentration:1 μg/mL Incubation Time:5, 10, 30, 60 min Result:Showed activity of activating p38 MAP kinase and Hsp27 in a time-dependent manner.Western Blot Analysis Cell Line:HaCaT cells Concentration:1, 2 μg/mL Incubation Time:6 or 8 h Result:Induced 50% expression of COX-2 and resulted in a twofold increased in PGE2 release.Western Blot Analysis Cell Line:siRNA-transfected HaCaT cells (without p38 MAP kinase expression)Concentration:1 μg/mL Incubation Time:24 h Result:Mediated induction of PGE2 was dependent on p38 activation.Cell Proliferation Assay Cell Line:HeLa, HEK-293, MCF-7, A549 cells Concentration:0-100 μM Incubation Time:24 h Result:Showed antiproliferation activity with IC50s of 38, 45.1, 41.5, and 40.8 μM for HeLa, HEK-293, A549, and MCF-7 cells, respectively.

Sertaconazole (1% (w/v); apply to the left ear, once) suppresses of TPA-induced ear edema CD-1 mice. Animal Model:CD-1 mice (TPA-induced ear edema model).Dosage:1% (w/v)Administration:Apply to the left ear, once.Result:Exhibited a significant reduction of inflammation in mice by mediating PGE2 release.

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GPCR/G Protein

Antibacterial

Antifection|Antibacterial

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99592-32-2

437.76

C20H15Cl3N2OS

>98% (HPLC)

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Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years