N,N'-Dimethylthiourea

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N,N'-二甲基硫脲 (DMTU) 是从大蒜中分离出来的，是一种口服活性羟自由基 ( OH) 清除剂，可在体外阻断活化的中性粒细胞产生 OH。

N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including OH scavenging and anti-inflammatory action.(In Vivo):N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks .

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DMTU

Others

Antioxidant

Antibacterial|organic anion transporter

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534-13-4

104.17

C3H8N2S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (959.97 mM)

CNC(=S)NC

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(-20℃)

With Ice Pack

≥ 2 years