AHN 1-055 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AHN 1-055 盐酸盐是多巴胺转运蛋白 (DAT) 和多巴胺摄取的抑制剂 (IC50 = 71 nM)。

AHN 1-055 hydrochloride is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). AHN 1-055 hydrochloride may serve as a lead for the development of agents for the treatment of cocaine abuse.(In Vivo):In adult male Sprague Dawley rats, AHN 1-055 hydrochloride (5 mg/kg; i.v.) inhibited the uptaking of brain dopamine with an IC50 of 311.8 ng/ml. The Cmax and T1/2 are 1.48 mg/L and 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution.

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Animal Model:Adult male Sprague Dawley rats (250-275 g)Dosage:5?mg/kg (Pharmacokinetic Analysis)Administration:I.v. administration Result:Cmax (1.48 mg/L); T1/2 (7.69 h).

3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride

GPCR/G Protein

Dopamine Receptor

EGFR (wt)|EGFR (L858R)|EGFR (L861Q)|EGFR (L858R/T790M)

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202646-03-5

379.87

C21H24ClF2NO

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (263.25 mM)

CN1[C@@H]2C[C@@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@H]1CC2.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years