3-Aminopropylphosphonic Acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

3-氨基丙基膦酸 (3-APPA) 是 GABA 的膦酸类似物，可作为 GABAB 受体的部分激动剂（放射性配体结合测定中的 IC50 = 1.5 μM）。

3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay). (In Vitro):3-aminopropylphosphonic acid (IC50 1.5 microM) and 4-aminobutyl-phosphonic acid (IC50 3.9 μM) were much more potent than anticipated from their relatively weak GABAB antagonist actions . 3-aminopropylphosphonic acid was a potent inhibitor (IC50 6μM) of the binding of [3H]GABA to rat brain membranes under GABAB conditions, i.e. in the presence of 0.1 mM isoguvacine and displaceable by 0.1 mM (+)-baclofen . (In Vivo):3-aminopropylphosphonic acid induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle. 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs. It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.

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Others

Other Targets

DNA/RNA Synthesis

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13138-33-5

139.091

C3H10NO3P

>98% (HPLC)

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NCCCP(O)(O)=O

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(-20℃)

With Ice Pack

≥ 2 years