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Propargylcholine
CAS No. 111755-76-1
Propargylcholine ( Propargylcholine (bromide) )
产品货号. M28160 CAS No. 111755-76-1
Propargylcholine 是一种炔烃修饰的胆碱类似物，可在铜绿假单胞菌中 Dgc 酶催化的二甲基甘氨酸去甲基化水平上抑制胆碱分解代谢。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥244 | 有现货 |
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| 10MG | ￥392 | 有现货 |
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| 25MG | ￥632 | 有现货 |
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| 50MG | ￥1070 | 有现货 |
|
| 200MG | ￥3474 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥258 | 有现货 |
|
生物学信息
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产品名称Propargylcholine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Propargylcholine 是一种炔烃修饰的胆碱类似物，可在铜绿假单胞菌中 Dgc 酶催化的二甲基甘氨酸去甲基化水平上抑制胆碱分解代谢。
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产品描述Propargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.
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体外实验Propargylcholine bromide (10, 50 μM; 24 h) incorporates into NIH 3T3 cells and shows strong staining in a concentration-dependent manner (fixed and stained with Alexa568-azide). Immunofluorescence Cell Line:NIH 3T3 cells Concentration:10, 50 μM Incubation Time:24 h Result:Showed strong staining proportional in intensity to the concentration of added Propargylcholine bromide.
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体内实验Propargylcholine bromide (P-Cho; 3.5-4.0 mg/kg; i.p; single daily for 6 days) effectivelyincorporates into newly synthesized myelin within 1 week of dosing and sustained presence beyond 6 weeks in rhesus monkey.
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同义词Propargylcholine (bromide)
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通路GPCR/G Protein
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靶点Antibacterial
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受体Bacterial|PGE2|COX-1|E. coli
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研究领域——
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适应症——
化学信息
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CAS Number111755-76-1
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分子量208.099
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分子式C7H14BrNO
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 125 mg/mL (600.67 mM)
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SMILES[Br-].C[N+](C)(CCO)CC#C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zhou Yin,et al. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21(4):481-487.
