CAY10786

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CAY10786 是 G 蛋白偶联受体 52 (GPR52，IC50 = 0.63 μM) 的拮抗剂。

CAY10786 is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).(In Vitro):CAY10786 reduces mutant huntingtin (mHTT) protein levels in STHdhQ7/Q111cells in a concentration-dependent manner. CAY10786 (3 μM) reduces apoptosis induced by growth factor deprivation in primary striatal neurons. (In Vivo):In the homozygous HdhQ140 mouse model of Huntington’s disease, CAY10786 (5 mg/kg) increases the latency to fall in the rotarod test and decreases striatal levels of soluble and insoluble mHTT.

——

GPR52 antagonist-1 (Compound 43) (5 mg/kg; i.p.; once a day for 4 weeks) reduces mHTT levels and rescues HD-related phenotypes in HdhQ140 mice.

GPR52 antagonist-1

Cell Cycle/DNA Damage

GPR

——

——

——

1239987-91-7

242.34

C15H14OS

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (1031.61 mM)

C(/C=C/CCC1=CC=CC=C1)(=O)C2=CC=CS2

——

(-20℃)

With Ice Pack

≥ 2 years