Cucurbit[8]uril

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cucurbit[8]uril 是一种有效、低毒、具有口服活性的蛋白质异二聚化超分子诱导剂。 Cucurbit[8]uril 诱导甲基紫精和萘功能化蛋白质的异二聚化。

Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy trans(In Vitro):Cucurbituril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%.Cucurbituril indeed selectively induces the heterodimerization of MV-eYFP with Np-eCFP. Cucurbituril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbituril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbituril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbituril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces.(In Vivo):Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice.

Cucurbituril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%.Cucurbituril indeed selectively induces the heterodimerization of MV–eYFP with Np–eCFP. Cucurbituril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbituril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbituril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins.The presence of Cucurbituril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces. Cell Viability Assay Cell Line:CHO-K1 cells Concentration:0~20 μM Incubation Time:48 hours Result:At the highest investigated concentration of 20 μM after 48 h, the relative cell viability dropped marginally to 86%.

Cucurbituril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice.

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Others

Other Targets

Antibacterial|P. aeruginosa

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259886-51-6

1329.12

C48H48N32O16

>98% (HPLC)

In Vitro:?DMSO : < 1 mg/mL (insoluble)

O=C1N2CN3[C@H]4[C@H]5N(CN6[C@H]7[C@H]8N(CN9[C@H]%10[C@H]%11N(CN%12[C@H]%13[C@H]%14N(CN%15[C@H]%16[C@H]%17N(CN%18[C@H]%19[C@H]%20N(CN%21[C@H]%22[C@H]%23N(CN1[C@H]1[C@@H]2N2CN4C(=O)N5CN7C(=O)N8CN%10C(=O)N%11CN%13C(=O)N%14CN%16C(=O)N%17CN%19C(=O)N%20CN%22C(=O)N%23CN1C2=O)C%21=O)C%18=O)C%15=O)C%12=O)C9=O)C6=O)C3=O

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(-20℃)

With Ice Pack

≥ 2 years